Aerobic Copper-Catalyzed O-Methylation with Methylboronic Acid.
نویسندگان
چکیده
The oxidative coupling of alkylboronic acids with oxygen nucleophiles offers a strategy for replacing toxic, electrophilic alkylating reagents. Although the Chan-Lam reaction has been widely applied in the arylation of heteroatom nucleophiles, O-alkylation with boronic acids is rare. We report a Cu-catalyzed nondecarboxylative methylation of carboxylic acids with methylboronic acid that proceeds in air with no additional oxidant. An isotope-labeling study supports an oxidative cross-coupling mechanism, in analogy to that proposed for Chan-Lam arylation.
منابع مشابه
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عنوان ژورنال:
- The Journal of organic chemistry
دوره 80 14 شماره
صفحات -
تاریخ انتشار 2015